Research – Testosterone Therapy and Type 2 Diabetes

Some interesting research came out on treating Type-2 diabetes with testosterone injections. A study published in June wanted to determine if “testosterone therapy (TTh) in men with hypogonadism [low testosterone] and type 2 diabetes mellitus (T2DM) improves glycaemic control and insulin sensitivity, and results in remission of T2DM.”

This was a comparative experiment with one group of men receiving the testosterone and a control group which received nothing:

A total of 356 men who had total testosterone levels ≤12.1 nmol/L (350 ng/dL) and symptoms of hypogonadism were included in the study and followed up for 11 years. All patients received standard diabetes treatment and 178 patients additionally received parenteral testosterone undecanoate 1000 mg every 12 weeks following an initial 6‐week interval. A control group comprised 178 hypogonadal patients who opted not to receive TTh.

The results were very encouraging indeed. A significant percentage of the group experienced remission of their diabetes (i.e., their diabetes disappeared) and nearly half achieved normal glucose regulation. Ninety percent achieved an HbA1c level of 8.5 mmol/L. In all, there were improvements in fasting glucose, HbA1c and fasting insulin:

Patients with hypogonadism and T2DM treated with testosterone had significant progressive and sustained reductions in fasting glucose, glycated haemoglobin (HbA1c) and fasting insulin over the treatment period. In the control group, fasting glucose, HbA1c and fasting insulin increased. Among the patients treated with testosterone 34.3% achieved remission of their diabetes and 46.6% of patients achieved normal glucose regulation. Of the testosterone‐treated group, 83.1% reached the HbA1c target of 47.5 mmol/mol (6.5%) and 90% achieved the HbA1c target of 53.0 mmol/mol (7%). In contrast, no remission of diabetes or reductions in glucose or HbA1c levels were noted in the control group. There were fewer deaths, myocardial infarctions, strokes and diabetic complications in the testosterone‐treated group.

The study concluded that testosterone therapy helps with insulin resistance and glycaemic control and could be a new form of treatment for Type 2s and men with low testosterone.

Conclusion

I’m pretty sure my testosterone levels are good for my age, but it can’t hurt to check when I go in for my blood work in a couple of months. After all, I thought I might have high iron levels, and I was wrong there. If they do turn out to be low, I’ll see what I can do about it naturally or with the hand of science.

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